Heating a mixture of 1,1-bis(methylthio)-2-nitroethene, a 1,2-diamine, a 2-formylbenzoic acid and a primary amine in EtOH for 3.5 h afforded the corresponding 2,3-disubstituted isoindolin-1-ones.
Benzoic acid occurs naturally free and bound as benzoic acid esters in many plant and animal species. Appreciable amounts have been found in most berries (around 0. 05%). Cranberries contain as much as 300-1300 mg free benzoic acid per kg fruit. Benzoic acid is a fungistatic compound that is widely used as a food preservative. It often is conjugated to.
Synthesis with 1,2 bond formation as the last step.16 Synthesis with 2.3 Bond Fonnation as the Last Step Haeflinger et al. 17 synthesized dihydrolysergic acid and its 14-substituted derivatives by formation of the indole ring as the last step using a nitrobenzo(f)quinoline, which was converted to the corresponding isonitrile (Figure 6).